Could Metformin Slow Human Aging? Scientists Review The Evidence

 

Facsimile Metformin Prescription

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A Diabetes Pill Is Reshaping the Anti-Aging Conversation

In A Nutshell

  • A new scientific review finds metformin, a decades-old diabetes drug, interacts with nearly every major biological process scientists link to aging
  • Animal studies show real lifespan gains, from a 36 percent increase in roundworms to a striking drop in biological age in monkeys, but human evidence stays far more mixed
  • One widely cited human study claiming a survival benefit has since failed to replicate, and a major clinical trial designed to settle the question has stalled since 2017
  • Metformin is not an approved anti-aging treatment, and researchers say it’s too soon for healthy people to take it hoping to live longer

There’s a decades-old diabetes drug scientists are now eyeing for something bigger: whether it can slow aging itself. According to a new scientific review, metformin, the go-to drug for type 2 diabetes, appears to touch many of the same biological switches that control how fast the body wears out.

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