Goodbye Ozempic, Hello TOFA? Obscure Pill Burned Fat Without Muscle Loss Or Weight Rebound From GLP-1s

 

Doctor measuring obese man stomach.

(Credit: © Kurhan - stock.adobe.com)

In a Nutshell

  • An oral compound called TOFA caused significant weight and fat loss in obese mice without reducing food intake or causing muscle loss, setting it apart from current obesity drugs.
  • TOFA worked by boosting how much energy cells burn, rather than suppressing appetite, and it also improved blood sugar, harmful blood fats, and fatty liver disease.
  • When combined with semaglutide or tirzepatide, TOFA outperformed

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