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Saturday, May 18, 2013

Popular Statin Found to Cut Exercise Benefits

The HMG-CoA reductase pathway, which is blocke...
The HMG-CoA reductase pathway, which is blocked by statins via inhibiting the rate limiting enzyme HMG-CoA reductase. (Photo credit: Wikipedia)
University of Missouri researchers have found that a popular cholesterol-lowering drug, typically prescribed to prevent heart disease, may actually hinder the positive benefits of exercise among obese and overweight adults.

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The finding that simvastatin — a generic type of statin sold under the brand name Zocor — may cut the benefits of exercise underscores new questions about the pros and cons of taking such cholesterol-lowering medicines.
"Fitness has proven to be the most significant predictor of longevity and health because it protects people from a variety of chronic diseases," said John Thyfault, an associate professor of nutrition and exercise physiology at MU.

"Daily physical activity is needed to maintain or improve fitness, and thus improve health outcomes. However, if patients start exercising and taking statins at the same time, it seems that statins block the ability of exercise to improve their fitness levels."

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