Drug Improves Mobility in Some MS Patients

FRIDAY, Feb. 27 (HealthDay News) -- The drug fampridine improves walking ability in some people with multiple sclerosis.

In a phase III study that included 301 patients, aged 18 to 70, the participants were randomly assigned to receive either 10 milligrams of fampridine or a placebo twice a day for 14 weeks. The patients' walking speed was assessed after two weeks, six weeks, 10 weeks and 14 weeks.

The number of timed walk responders -- those who achieved a faster walking speed in at least three of the four assessments while on treatment compared to when they weren't on treatment -- was 78 out of 224 (35 percent) in the fampridine group and six out of 72 (8 percent) in the placebo group. The patients in the fampridine group also showed greater improvement in leg strength.

Eleven patients (5 percent) in the fampridine group had to withdraw from the study due to adverse events, but only two serious adverse events (focal seizure and severe anxiety) were considered to be connected with the drug, according to Andrew Goodman, of the University of Rochester Medical Center, and colleagues. But they added that the risk of seizure noted in previous studies seems to increase in a dose-dependent way with fampridine.

"Treatment with fampridine produces clinically meaningful improvement in walking ability in some people with multiple sclerosis, irrespective of disease course type or concomitant treatment with immunomodulators," the researchers concluded.

The study was published in this week's edition of The Lancet.

MS patients suffer a progressive decline in mobility, but there are few treatment options available to complement physiotherapy. While it has been suggested that fampridine may improve visual function, strength, walking ability, fatigue and endurance in MS patients, there are questions about the drug's efficacy and safety.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about multiple sclerosis.

Documents on Seroquel show drugmaker

TRENTON, N.J. (AP) — Internal AstraZeneca reports and e-mails written by company officials show they knew a decade ago that their psychiatric drug Seroquel caused diabetes and major weight gain, plaintiffs' lawyers said Friday after releasing dozens of the previously sealed documents.

"They not only failed to warn about the risk of diabetes, but they marketed it as not having that risk," said Houston attorney Ed Blizzard, one of the lead attorneys representing roughly 15,000 plaintiffs suing the British drugmaker.

The plaintiffs claim Seroquel, approved for treating schizophrenia and bipolar disorder, caused diabetes, weight gain and related health problems, from kidney failure and heart attacks to amputations and damage to the pancreas, which makes insulin.

AstraZeneca spokesman Tony Jewell said plaintiffs' lawyers are "mischaracterizing that we knew that it caused diabetes." He said it remains unresolved whether Seroquel causes diabetes, and that AstraZeneca PLC has shared all relevant and required data with the Food and Drug Administration, both before and after the FDA approved Seroquel as safe and effective in 1997.

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Bypass or Stents?


Some experts say the choice is up to you

http://yourtotalhealth.ivillage.com/bypass-truly-better-than-stenting.html?nlcid=hr|02-27-2009| Results from a new study may make it easier for heart patients and their doctors to decide on a surgical treatment for dangerously blocked arteries. Researchers compared two groups: people who had bypass surgery and those who had angioplasty with stenting. While interpretations of the study results differ, some experts say the pros and cons of the procedures balance out, suggesting that the ultimate choice is up to the patient.

Plus: Breathing exercises before heart surgery may speed recovery and reduce pneumonia risk afterward. Consider asking your heart doctor if breathing workouts could help you.

Chemists Shed Light On Health Benefits Of Garlic

ScienceDaily (Jan. 31, 2009) — A Queen's-led team has discovered the reason why garlic is so good for us.
Researchers have widely believed that the organic compound, allicin – which gives garlic its aroma and flavour – acts as the world's most powerful antioxidant. But until now it hasn't been clear how allicin works, or how it stacks up compared to more common antioxidants such as Vitamin E and coenzyme Q10, which stop the damaging effects of radicals.
http://www.sciencedaily.com/images/2009/01/090130154901-large.jpg
Garlic. Chemists have discovered the reason why garlic is so good for us. (Credit: iStockphoto/Jorge Farres Sanchez)

Super Spice Secrets: Can This Miracle Spice Stop Cancer, Alzheimer's and Arthritis?

turmeric, curcumin, india, herbs, spices, cancer, alzheimer's, arthritisBy Dr. Mercola

For more than 5,000 years, turmeric has been an important part of Eastern cultural traditions, including traditional Chinese medicine and Ayurveda. Valued for its medicinal properties and warm, peppery flavor, this yellow-orange spice has more recently earned a name for itself in Western medicine as well.

Turmeric comes from the root of the Curcuma longa plant, which is native to Indonesia and southern India, and is widely used as an ingredient in curry dishes and yellow mustard. As research into this powerful spice has increased, it has emerged as one of nature’s most powerful potential healers.

Said Dr. David Frawely, founder and director of the American Institute for Vedic Studies in Santa Fe, New Mexico:

“If I had only one single herb to depend upon for all possible health and dietary needs, I would without much hesitation choose the Indian spice Turmeric. There is little it cannot do in the realm of healing and much that no other herb is able to accomplish.

Turmeric has a broad spectrum of actions, mild but certain effects, and is beneficial for long term and daily usage. Though it is a common spice, few people, including herbalists know of its great value and are using it to the extent possible. It is an herb that one should get to know and live with.”

Turmeric’s Beneficial Effects in a Nutshell

Strengthens and improves digestion

  • Reduces gas and bloating
  • Assists in the digestion of protein and with rice and bean dishes
  • Improves your body's ability to digest fats
  • Promotes proper metabolism, correcting both excesses and deficiencies
  • Maintains and improves intestinal flora
  • Improves elimination of wastes and toxins

Supports healthy liver function and detox

  • Turmeric helps increase bile flow making it a liver cleanser that can rejuvenate your liver cells and recharge their capability to break down toxins
  • Helps to prevent alcohol and other toxins from being converted into compounds that may be harmful to your liver
  • Supports formation of healthy tissue

Purifies your blood

  • Stimulates formation of new blood tissue
  • Anti-inflammatory: Helps to reduce irritation to tissues characterized by pain, redness, swelling and heat

Contains curcuminoids that fight cancer, arthritis, and Alzheimer’s

  • Curcuminoids are potent phytonutrients (plant-based nutrients) that contain powerful antioxidant properties
  • Counteract the damaging effects of free radicals in your body
  • Relieve arthritis pain and stiffness, anti-inflammatory agent
  • Anti-carcinogenic: “Curcumin has been shown to prevent a large of number of cancers in animal studies. Laboratory data indicate that curcumin can inhibit tumor initiation, promotion, invasion, angiogenesis and metastasis.”[1]
  • Supports treatment of Alzheimer’s disease: “Because Alzheimer's disease is caused in part by amyloid-induced inflammation, curcumin has been shown to be effective against Alzheimer's. Clinical trials are in progress at UCLA with curcumin for Alzheimer's.”[2]

Curcumin: Turmeric’s Active Anti-Inflammatory “Ingredient”

Most notably turmeric is known for its potent anti-inflammatory properties, which come from curcumin -- the pigment that gives turmeric its yellow-orange color, and which is thought to be responsible for many of its medicinal effects. There are an estimated three to five grams of curcumin in 100 grams of turmeric.

Curcumin has been shown to influence more than 700 genes, and it can inhibit both the activity and the synthesis of cyclooxygenase-2 (COX2) and 5-lipooxygenase (5-LOX), as well as other enzymes that have been implicated in inflammation.[3]

Turmeric’s Cancer-Fighting Properties

In India where turmeric is widely used, the prevalence of four common U.S. cancers -- colon, breast, prostate and lung -- is 10 times lower. In fact, prostate cancer, which is the most frequently diagnosed cancer in U.S. men, is rare in India and this is attributed, in part, to turmeric.

Numerous studies have looked into this potential cancer-fighting link, with promising results. For instance, curcumin has been found to:

  • Inhibit the proliferation of tumor cells
  • Inhibit the transformation of cells from normal to tumor
  • Help your body destroy mutated cancer cells so they cannot spread throughout your body
  • Decrease inflammation
  • Enhance liver function
  • Inhibit the synthesis of a protein thought to be instrumental in tumor formation
  • Prevent the development of additional blood supply necessary for cancer cell growth

As for the results of research studies, a study in Biochemical Pharmacology found that curcumin can slow the spread of breast cancer cells to the lungs in mice.[4]

"Curcumin acts against transcription factors, which are like a master switch," said lead researcher, Bharat Aggarwal. "Transcription factors regulate all the genes needed for tumors to form. When we turn them off, we shut down some genes that are involved in the growth and invasion of cancer cells."

A second study in Biochemical Pharmacology also found that curcumin inhibits the activation of NF-kappaB, a regulatory molecule that signals genes to produce a slew of inflammatory molecules (including TNF, COX-2 and IL-6) that promote cancer cell growth.[5]

Turmeric’s Essential Role for Your Liver

Your liver’s primary role is to process and remove toxins carried in your bloodstream. When functioning at its peak, it can filter up to two liters of blood per minute and easily break apart toxic molecules to reduce their toxicity. Your liver is also a crucial part of vitamin, mineral, protein, fat, carbohydrate and hormonal metabolism.

However, poor diet, allergens, pollution and stress can cause your liver to become sluggish, and this can impair its vital functions. This is where turmeric can be a very useful part of your liver support system. Studies have shown that it:

  • May increase important detoxification enzymes in your liver
  • Induces the formation of a primary liver detoxification enzyme, glutathione S-transferase (GST) enzymes

Turmeric is also a natural cholagogue, a medicinal agent that promotes the discharge of bile from your system. Increased bile flow is important to help your liver detoxify and to help your body digest fats.

Turmeric for Your Heart, Brain and Overall Health

Turmeric inhibits free radical damage of fats, including cholesterol. When cholesterol is damaged in this way, or oxidized, it can then damage your blood vessels and lead to a heart attack or stroke. Therefore, research suggests that turmeric’s ability to prevent the oxidation of cholesterol may be beneficial for your heart. It’s also rich in vitamin B6, high intakes of which are associated with a reduced risk of heart disease.

Meanwhile, turmeric appears to be highly protective against neurodegenerative diseases. In fact, in India levels of neurological diseases such as Alzheimer’s are very low, and studies have shown that curcumin can slow the progression of Alzheimer’s in mice. The compound has also proven capable of blocking the progression of multiple sclerosis.

Further, Professor Moolky Nagabhushan from the Loyola University Medical Center, Chicago, IL, who has been studying turmeric for the last 20 years, believes that turmeric can protect against harmful environmental chemicals, and in so doing protect against childhood leukemia. The research showed that curcumin in turmeric can:[7]

  • Inhibit the toxicity of polycyclic aromatic hydrocarbons (PAHs) (cancer-causing chemicals in the environment)
  • Inhibit radiation-induced chromosome damage
  • Prevent the formation of harmful heterocyclic amines and nitroso compounds, which may result in the body when eating certain processed foods, such as processed meat products
  • Irreversibly inhibit the multiplication of leukemia cells in a cell culture

Turmeric's volatile oils also have external anti-bacterial action. As such, they may help prevent bacterial wound infections and accelerate wound healing. Johnson & Johnson even sells a curcumin-containing Band-Aid in India!

And the therapeutic potential of turmeric and curcumin do not end there. Evidence suggests the spice may also be beneficial for:

  • Cystic fibrosis
  • Type 2 diabetes
  • Crohn’s disease
  • Psoriasis
  • Rheumatoid arthritis
  • Cataracts
  • Gallstones
  • Muscle regeneration
  • Inflammatory bowel disease

Which Type of Turmeric is Best?

For use in cooking, choose a pure turmeric powder, rather than a curry powder. At least one study has found that curry powders tend to contain very little curcumin, compared to turmeric powder. Turmeric is also available in supplement form and for many this is a more convenient method to obtain these health benefits discussed above, especially if they are from a high-quality organic source and if one doesn’t particularly enjoy the taste of curry.

On my recent trip to India I was able to find a company called Organic India that produces probably some of the best Indian herbs on the planet.

FDA Approves New Gout Medicine

For the first time in more than forty years there's a new medication receiving FDA approval for the treatment of gout.

That often affects one joint, which is most often the big toe, but can happen with many joints in the body.

It's the most common inflammatory arthritis is men over age 40.

The medicine is called Uloric.

It's a once daily oral medication that works by blocking an enzyme which helps prevent uric acid production, lowering uric acid levels.

Bulge Zapper Not Available in US -- Yet

(Feb. 12) - A relatively new medical treatment has the potential to minimize some of those unsightly bulges -- without surgery. It's not approved in the U.S., but it may be in the future. So how much promise does the technology hold?
The UltraShape system uses a noninvasive ultrasound device designed to target and destroy fat cells only and leave surrounding tissue unaffected. The patient's body then naturally metabolizes the fat released from the cells, studies have found
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Stress Adds Years to Face

Wrinkles are not due to genetics alone but also to stressful environmental factors, such as a divorce, abnormal weight loss and use of antidepressants, according to a study published Tuesday.

"A person's heritage may initially dictate how they age -- but if you introduce certain factors into your life, you will certainly age faster. Likewise, if you avoid those factors, you can slow down the hands of time," said study author Bahaman Guyuron, an American Society of Plastic Surgeons (ASPS) member. MORE.....

Teen TV Time Linked to Adult Depression

Teens who spend too much time watching television or playing video games have a higher risk for depression as young adults. And the more media teens were exposed to, the higher the risk, especially among males.

A study by the University of Pittsburgh School of Medicine used data from the National Longitudinal Survey of Adolescent Health and involved more than 4,100 teens who were not depressed when the survey began in 1995. They were asked how many hours they spent each day the previous week watching television, playing computer games or listening to the radio. (This was before the Internet was in wide use.) The teens reported an average media exposure of 5.68 hours each day. Seven years later, at an average age of 21.8, “Participants had significantly greater odds of developing depression for each hour of daily television views,” the authors wrote.

The odds of developing depression rose eight percent for each additional hour of television watched each day and five percent for overall electronic media.

Researchers aren’t sure exactly why watching television leads to depression, but study author Dr. Brian Primack said it could be linked to all the depressing events on television. “Television emphasizes bad news, and repeated exposure to it might be internalized,” he told HealthDay News.

TV commercials might also be at fault. “You see about 20,000 television advertisements a year, and a large proportion of them dwell on the fact that life is not perfect,” Primack said.

In addition television might be replacing other activities, such as social or athletic activities that protect against stress and depression, or television could cut down on the amount of sleep.

“It really does seem that television exposure is what occurs first and then depression is what occurs later,” said Dr. Primack. “This does not prove causality but it certainly suggests it.”

http://www.newsmax.com/health/teen_TV_adult_depression/2009/02/04/178278.html