Alternative medicine is going mainstream, and top-notch hospitals are embracing various forms of alternative and complementary medicine. According to the American Hospital Association, more than one-third of U.S. hospitals offer at least one type of complementary medicine, which includes acupuncture, homeopathy, chiropractic, nutrition, massage therapy and herbal medicine. For example, the prestigious Memorial Sloan-Kettering Cancer Center offers acupuncture for relief of nausea from surgery or chemotherapy. The growing field is even referred to by a new name—CAM—an acronym for complementary alternative medicine. MORE
Learning God's Healthy way to a better Life!
Alternative Medicine is Going Mainstream
By: Sylvia Booth Hubbard
Touching Helps Couples Reduce Stress
Couples may be able to enhance one another's health by being more physically affectionate with one another, new research in Psychosomatic Medicine shows.
Couples who underwent training in "warm touch enhancement" and practiced the technique at home had higher levels of oxytocin, also known as the "love hormone" and the "cuddle chemical," while their levels of alpha amylase, a stress indicator, were reduced, Dr. Julianne Holt-Lunstad of Brigham Young University in Salt Lake City, Utah, and her colleagues found. MORE
Couples who underwent training in "warm touch enhancement" and practiced the technique at home had higher levels of oxytocin, also known as the "love hormone" and the "cuddle chemical," while their levels of alpha amylase, a stress indicator, were reduced, Dr. Julianne Holt-Lunstad of Brigham Young University in Salt Lake City, Utah, and her colleagues found. MORE
Coffee Lowers Risk of Oral Cancers
New research indicates that drinking coffee lowers the risk of developing cancer of the oral cavity or throat, at least in the general population of Japan.
The consumption of coffee in Japan is relatively high, as is the rate of cancer of the esophagus in men. To look into any protective effect of coffee drinking, Dr. Toru Naganuma of Tohoku University, Sendai, and colleagues, analyzed data from the population-based Miyagi Cohort Study in Japan.
The study included information about diet, including coffee consumption. Among more than 38,000 study participants aged 40 to 64 years with no prior history of cancer, 157 cases of cancer of the mouth, pharynx and esophagus occurred during 13 years of follow up.
Compared with people who did not drink coffee, those who drank one or more cups per day had half the risk of developing these cancers, Naganuma's group reports in the American Journal of Epidemiology.
They note that the reduction in risk included people who are at high risk for these cancers, namely, those who were current drinkers and/or smokers at the start of the study.
"We had not expected that we could observe such a substantial inverse association with coffee consumption and the risk of these cancers," Naganuma commented to Reuters Health, "and the inverse association in high-risk groups for these cancers as well."
The researchers conclude in their article, "Although cessation of alcohol consumption and cigarette smoking is currently the best known way to help reduce the risk of developing these cancers, coffee could be a preventive factor in both low-risk and high-risk populations."
SOURCE: American Journal of Epidemiology, December 15, 2008.
The consumption of coffee in Japan is relatively high, as is the rate of cancer of the esophagus in men. To look into any protective effect of coffee drinking, Dr. Toru Naganuma of Tohoku University, Sendai, and colleagues, analyzed data from the population-based Miyagi Cohort Study in Japan.
The study included information about diet, including coffee consumption. Among more than 38,000 study participants aged 40 to 64 years with no prior history of cancer, 157 cases of cancer of the mouth, pharynx and esophagus occurred during 13 years of follow up.
Compared with people who did not drink coffee, those who drank one or more cups per day had half the risk of developing these cancers, Naganuma's group reports in the American Journal of Epidemiology.
They note that the reduction in risk included people who are at high risk for these cancers, namely, those who were current drinkers and/or smokers at the start of the study.
"We had not expected that we could observe such a substantial inverse association with coffee consumption and the risk of these cancers," Naganuma commented to Reuters Health, "and the inverse association in high-risk groups for these cancers as well."
The researchers conclude in their article, "Although cessation of alcohol consumption and cigarette smoking is currently the best known way to help reduce the risk of developing these cancers, coffee could be a preventive factor in both low-risk and high-risk populations."
SOURCE: American Journal of Epidemiology, December 15, 2008.
Fosomax-Type Drugs Linked to Jaw Necrosis
Researchers at the University Of Southern California, School Of Dentistry release results of clinical data that links oral bisphosphonates to increased jaw necrosis. The study is among the first to acknowledge that even short-term use of common oral osteoporosis drugs may leave the jaw vulnerable to devastating necrosis, according to the report appearing in the January 1 Journal of the American Dental Association (JADA).
Osteoporosis currently affects 10 million Americans. Fosomax is the most widely prescribed oral bisphosphonate, ranking as the 21st most prescribed drug on the market since 2006, according to a 2007 report released by IMS Health.
“Oral Bisphosphonate Use and the Prevalence of Osteonecrosis of the Jaw: An Institutional Inquiry” is the first large institutional study in the U.S. to investigate the relationship between oral bisphosphonate use and jaw bone death, said principal investigator Parish Sedghizadeh, assistant professor of clinical dentistry with the USC School of Dentistry.
After controlling for referral bias, nine of 208 healthy School of Dentistry patients who take or have taken Fosamax for any length of time were diagnosed with osteonecrosis of the jaw (ONJ). The study’s results are in contrast to drug makers’ prior assertions that bisphosphonate-related ONJ risk is only noticeable with intravenous use of the drugs, not oral usage, Sedghizadeh said. “We’ve been told that the risk with oral bisphosphonates is negligible, but four percent is not negligible,” he said.
Most doctors who have prescribed bisphosphonates have not told patients about any oral health risks associated with the use of the drugs, despite even short-term usage posing a risk due to the drug’s tenacious 10-year half life in bone tissue. Lydia Macwilliams of Los Angeles said no one told her about the risk posed by her three years of Fosamax usage until she became a patient of Sedghizadeh at the School of Dentistry. “I was surprised,” she said. “My doctor who prescribed the Fosamax didn’t tell me about any possible problems with my teeth.”
Macwilliams was especially at risk for complications because she was to have three teeth extracted. The infection is a biofilm bacterial process, meaning that the bacteria infecting the mouth and jaw tissues reside within a slimy matrix that protects the bacteria from many conventional antibiotic treatments, and bisphosphonate use may make the infection more aggressive in adhering to the jaw, Sedghizadeh said. The danger is especially pronounced with procedures that directly expose the jaw bone, such as tooth extractions and other oral surgery. After her extractions, two of the three extraction sites had difficulty healing due to infection, Macwilliams said. Luckily, with treatment as well as the rigorous oral hygiene regimen USC dentists developed especially for patients with a history of bisphosphonate usage, the remaining sites slowly but fully healed. “It took about a year to heal,” she said, “but it’s doing just fine now.”
Sedghizadeh hopes to have other researchers confirm his findings and thus encourage more doctors and dentists to talk with patients about the oral health risks associated with the widely used drugs. The results confirm the suspicions of many in the oral health field, he said. “Here at the School of Dentistry we’re getting two or three new patients a week that have bisphosphonate-related ONJ,” he said, “and I know we’re not the only ones seeing it.”
Bone Drugs Tied to Esophageal Cancer
Merck's popular osteoporosis drug Fosamax and other similar drugs may carry a risk for esophageal cancer, a Food and Drug Administration official said on Wednesday.
Diane Wysowski of the FDA's division of drug risk asessment said researchers should check into potential links between so called bisphosphonate drugs and cancer.
In a letter in Thursday's New England Journal of Medicine, Wysowski said since the initial marketing of Fosamax, known generically as alendronate, in 1995, the FDA has received 23 reports in which patients developed esophageal tumors.
Typically, two years lapsed between the start of the drug and the development of esophageal cancer. Eight patients died, she reported.
In Europe and Japan, 21 cases involving Fosamax have been logged, with another six instances where Procter & Gamble's Actonel or risedronate and Didronel or etidronate, and Roche's Boniva (ibandronate) may have been involved. Six of those people died.
Esophagitis, which is an inflammation of the lining of the tube carrying food to the stomach, is already know to be a side effect of the drugs, which is why patients are instructed to remain upright for at least a half hour after taking them.
In addition, Wysowski said, doctors should avoid prescribing the drugs to people with Barrett's esophagus, which is a change in the lining that leads to the stomach. It is often found in people with acid reflux disease and itself increases the risk of cancer.
In November the FDA said that clinical trial data showed no overall risk of heart rhythm problems in patients taking bisphosphonates.
However, the FDA also said it was aware of conflicting findings in other studies and was considering whether conducting further studies to investigate the risk were feasible.
The drugs aim to treat bone-weakening osteoporosis by increasing bone mass. An estimated 10 million Americans, mostly women, have osteoporosis.
Ask An Expert: Erection but No Climax
Question:
I am a 59-year-old male. I can get and maintain an erection, but cannot climax. This is starting to affect me emotionally. What could cause this problem and what can be done about it?
Answer:
Male sexuality is complex. Successive stages of desire, arousal, erection, ejaculation, orgasm and relaxation are involved. To be successful, a man's hormones, nerves, blood vessels and mind must all be in sync.
It sounds like you have no problem with the first three stages of sex. Although most men lump ejaculation and orgasm together under the term "climax," they are actually separate events, and each can be thrown off by medical or psychological difficulties.
Delayed ejaculation can result from alcohol, medications (especially some antidepressants and antihypertensives), lack of sufficient sexual stimulation, or stress and worry — including worry about sex itself. Retrograde, or "dry" ejaculation occurs when semen is propelled back into the bladder; diabetes and medical and surgical treatments for prostate disease are the leading culprits. Failure to ejaculate can be caused by any of the factors that can delay ejaculation as well as by spinal cord conditions and prostate surgery.
Although ejaculation is almost always accompanied by the pleasurable sensation of orgasm, orgasm may lose much of its intensity. In addition, some men can experience orgasm without erections or ejaculation. All of the problems that inhibit ejaculation can also impair or prevent orgasm; medication, alcohol and psychosocial factors are most common.
The first thing to do is to evaluate your medications — but even if you suspect a drug is to blame, don't make changes without your doctor's cooperation. You can, and should, work on alcohol if drinking is a problem. If you are generally healthy, a specific serious medical problem is unlikely, so you can try to help yourself by relaxing about ejaculation and experimenting with sexual stimulation. If problems persist, ask your doctor about seeing specialists in medical and psychological aspects of sexuality.
Harvey B. Simon, M.D. is an Associate Professor of Medicine at Harvard Medical School and a member of the Health Sciences Technology Faculty at Massachusetts Institute of Technology. He is the founding editor of Harvard Men's Health Watch (www.health.harvard.edu) and the author of six consumer health books, including The Harvard Medical School Guide to Men's Health (Simon and Schuster, 2002) and The No Sweat Exercise Plan. Lose Weight, Get Healthy and Live Longer (McGraw-Hill, 2006). Dr. Simon practices at the Massachusetts General Hospital; he received the London Prize for Excellence in Teaching from Harvard and MIT.
High Vitamin C Linked to Lower Blood Pressure
A study in young adult women links high blood levels of vitamin C with lower blood pressure.
This "strongly suggests that vitamin C is specifically important in maintaining a healthy blood pressure," lead author Dr. Gladys Block, of the University of California, Berkeley, told Reuters Health.
Previous research linked high plasma levels of vitamin C with lower blood pressure among middle-age and older adults, typically those with higher than optimal blood pressure readings, Block and colleagues report in the Nutrition Journal.
The current study involved 242 black and white women, between 18 and 21 years old, with normal blood pressures, who were participants in the National Heart, Lung and Blood Institute Growth and Health Study. The girls had entered the trial when they were 8 to 11 years old. Over a 10-year period, their plasma levels of ascorbic acid (vitamin C) and blood pressure were monitored.
At year 10, Block and her colleagues found that blood pressure, both the systolic and diastolic (top and bottom reading), was inversely associated with ascorbic acid levels.
Specifically, women with the highest levels of ascorbic acid had a decline of about 4.66 mm Hg in systolic and 6.04 mm Hg in diastolic blood pressure compared with women with the lowest ascorbic acid levels. This difference still held true after researchers allowed for differences in body mass, race, education levels, and dietary fat and sodium intake.
Women with the lowest levels of plasma ascorbic acid likely consumed average amounts of fruits, vegetables, and fortified foods while those with the highest plasma ascorbic acid levels likely ate diets rich in fruits and vegetables or took multivitamins or vitamin C supplements, the researchers note.
Further analyses of vitamin C and blood pressure changes over the previous year, "also strongly suggested that the people with the highest blood level of vitamin C had the least increase in blood pressure," Block said.
Since these findings infer a possible association between vitamin C and blood pressure in healthy young adults, Block and colleagues call for further investigations in this population.
SOURCE: Nutrition Journal, December 17, 2008
Grape Seed Compound Kills Leukemia Cells
By: Sylvia Booth Hubbard
A natural compound extracted from grape seeds makes laboratory leukemia cells commit suicide, according to a new study by the University of Kentucky. When exposed to the extract, 76 percent of the leukemia cells were dead within 24 hours.
The extract forces leukemia cells to commit “apoptosis,” or cell suicide, which is a kind of programmed cell death that cells in the body undergo either in the normal course of growth and development or when something goes wrong with them. Leukemia and other cancers block the cell signaling pathway that allows apoptosis—this is how cancer keeps the defenses of the body at bay. Grape seed extract activates a protein called JNK that regulates the apoptotic pathway and allows damaged cells to commit suicide.
Grape seed extract has already shown beneficial activity in other laboratory cancer cell lines, including breast, skin, lung, and prostate cancers. Before the new study, however, no one had tested the effects of grape seed on hematological cancers, and neither had anyone found the exact mechanism involved.
“What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grape seed extract fits into this category,” said study author Xianglin Shi, Ph.D., who emphasized that research is still in an early stage. Hematological cancers, including leukemia, caused almost 54,000 deaths in 2006, making them the fourth leading cause of cancer death in the United States.
Pollution at Home Often Unrecognized
Many people may be surprised by the number of chemicals they are exposed to through everyday household products, a small study finds, suggesting, researchers say, that consumers need to learn more about sources of indoor pollution.
In interviews with 25 women who'd had their homes and bodies tested for various environmental pollutants, researchers found that most were surprised and perplexed by the number of chemicals to which they'd been exposed.
The women had been part of a larger study conducted by the Silent Spring Institute in which their homes and urine samples were tested for 89 environmental contaminants -- including pesticides and chemicals found in plastics, cleaning products and cosmetics.
An average of 20 chemicals was detected for each study participant.
Much is unknown about the possible health effects of the array of chemicals in everyday household products. But certain chemicals -- like phthalates and bisphenol-A, found in plastics -- have been linked to potential risks, including hormonal effects and higher risks of certain cancers, though the evidence mainly comes from research in lab animals.
Other household chemicals are known to irritate the skin, eyes and airways, and may exacerbate asthma, for example. Many more chemicals found in cleaning products, cosmetics and other household staples remain untested.
Chemicals that accumulate in household dust or urine likely come from a range of sources, so it is not always clear how to reduce people's exposure, according to Dr. Rebecca Gasior Altman, the lead researcher on the new study.
However, there are still measures that people can take, Altman, a lecturer in community health at Tufts University in Boston, told Reuters Health.
In the original study, she noted, women were given advice based on their particular chemical exposures -- such as reducing pesticide use or using fragrance-free detergent and personal-care products.
The term "fragrance" on household-product labels can signal the presence of potentially harmful chemicals. One of the uses of phthalates, for example, is to stabilize fragrances.
For the current study, published in the Journal of Health and Social Behavior, Altman and her colleagues interviewed two dozen women who'd taken part in the Silent Spring study to see how people tend to react to information on their household chemical exposure.
They found that the women were generally surprised at the range of chemicals detectable in their homes and bodies. They were also surprised that even some banned substances, such as the pesticide DDT, were detected (as these chemicals persist in the environment).
With many unanswered questions about the health effects of household chemicals, some experts worry that giving people information about their everyday exposures will provoke unnecessary fear, Altman's team notes.
However, the researchers found that women in their study were typically not alarmed, and instead wanted "more rather than less" information on the issue.
SOURCE: Journal of Health and Social Behavior, December 2008.
In interviews with 25 women who'd had their homes and bodies tested for various environmental pollutants, researchers found that most were surprised and perplexed by the number of chemicals to which they'd been exposed.
The women had been part of a larger study conducted by the Silent Spring Institute in which their homes and urine samples were tested for 89 environmental contaminants -- including pesticides and chemicals found in plastics, cleaning products and cosmetics.
An average of 20 chemicals was detected for each study participant.
Much is unknown about the possible health effects of the array of chemicals in everyday household products. But certain chemicals -- like phthalates and bisphenol-A, found in plastics -- have been linked to potential risks, including hormonal effects and higher risks of certain cancers, though the evidence mainly comes from research in lab animals.
Other household chemicals are known to irritate the skin, eyes and airways, and may exacerbate asthma, for example. Many more chemicals found in cleaning products, cosmetics and other household staples remain untested.
Chemicals that accumulate in household dust or urine likely come from a range of sources, so it is not always clear how to reduce people's exposure, according to Dr. Rebecca Gasior Altman, the lead researcher on the new study.
However, there are still measures that people can take, Altman, a lecturer in community health at Tufts University in Boston, told Reuters Health.
In the original study, she noted, women were given advice based on their particular chemical exposures -- such as reducing pesticide use or using fragrance-free detergent and personal-care products.
The term "fragrance" on household-product labels can signal the presence of potentially harmful chemicals. One of the uses of phthalates, for example, is to stabilize fragrances.
For the current study, published in the Journal of Health and Social Behavior, Altman and her colleagues interviewed two dozen women who'd taken part in the Silent Spring study to see how people tend to react to information on their household chemical exposure.
They found that the women were generally surprised at the range of chemicals detectable in their homes and bodies. They were also surprised that even some banned substances, such as the pesticide DDT, were detected (as these chemicals persist in the environment).
With many unanswered questions about the health effects of household chemicals, some experts worry that giving people information about their everyday exposures will provoke unnecessary fear, Altman's team notes.
However, the researchers found that women in their study were typically not alarmed, and instead wanted "more rather than less" information on the issue.
SOURCE: Journal of Health and Social Behavior, December 2008.
Food Additive Jump-Starts Lung Cancer
By: Sylvia Booth Hubbard
Alarming new research shows that inorganic phosphates, which are commonly added to many processed foods, may accelerate the growth of lung cancer tumors and even trigger the development of tumors in people predisposed to lung cancer. Phosphates are routinely added to food products such as cheeses, meats, bakery products, and beverages in order to improve texture and increase water retention.
The research, which was conducted at Seoul National University and appears in the January issue of the American Thoracic Society’s magazine American Journal of Respiratory and Critical Care Medicine, was carried out with mice. Study leader Myung-Haing Cho, D.V.M., Ph.D., said, “Our study indicates that increased intake of inorganic phosphates strongly stimulates lung cancer development in mice, and suggests that dietary regulation of inorganic phosphates may be critical for lung cancer treatment as well as prevention.”
Cancer of the lung is the most lethal of all cancers, and non-small cell lung cancer (NSCLC) is the form it takes more than 75 percent of the time. Previous research has shown that 9 out of 10 cases of NSCLC were linked to the activation of signaling pathways in lung tissue, and the new research shows that inorganic phosphates can stimulate the same pathways. “Lung cancer is a disease of uncontrolled cell proliferation in lung tissues,” said Dr. Cho, “and disruption of signaling pathways in those tissues can confer a normal cell with malignant properties.”
Lung cancer-model mice used in the study received a four-week diet of either 0.5 or 1.0 percent phosphate, which is an amount that simulates modern human diets. When the effects of the two levels of dietary phosphates were analyzed, the diet higher in phosphates, according to Dr. Cho, “caused an increase in the size of the tumors and stimulated growth of the tumors.”
Dr. Cho said that while the 0.5 amount of phosphate was defined as close to the equivalent “normal” amount in the average human diet today, the real-world equivalent may be closer to the 1.0 amount or may even exceed it. “In the 1990s, phosphorous-containing food additives contributed an estimated 470 mg per day to the average daily adult diet,” Cho said. “However, phosphates are currently being added much more frequently to a large number of processed foods, including meats, cheeses, beverages, and bakery products. As a result, depending on individual food choices, phosphorous intake could be increased by as much as 1000 mg per day.”
Future studies will seek to determine “safe” levels of inorganic phosphates. Future research will also address possible involvement of phosphates in the development of lung cancer in smokers, since up to this time no one has known why some smokers develop lung cancer while others never do.
Alarming new research shows that inorganic phosphates, which are commonly added to many processed foods, may accelerate the growth of lung cancer tumors and even trigger the development of tumors in people predisposed to lung cancer. Phosphates are routinely added to food products such as cheeses, meats, bakery products, and beverages in order to improve texture and increase water retention.
The research, which was conducted at Seoul National University and appears in the January issue of the American Thoracic Society’s magazine American Journal of Respiratory and Critical Care Medicine, was carried out with mice. Study leader Myung-Haing Cho, D.V.M., Ph.D., said, “Our study indicates that increased intake of inorganic phosphates strongly stimulates lung cancer development in mice, and suggests that dietary regulation of inorganic phosphates may be critical for lung cancer treatment as well as prevention.”
Cancer of the lung is the most lethal of all cancers, and non-small cell lung cancer (NSCLC) is the form it takes more than 75 percent of the time. Previous research has shown that 9 out of 10 cases of NSCLC were linked to the activation of signaling pathways in lung tissue, and the new research shows that inorganic phosphates can stimulate the same pathways. “Lung cancer is a disease of uncontrolled cell proliferation in lung tissues,” said Dr. Cho, “and disruption of signaling pathways in those tissues can confer a normal cell with malignant properties.”
Lung cancer-model mice used in the study received a four-week diet of either 0.5 or 1.0 percent phosphate, which is an amount that simulates modern human diets. When the effects of the two levels of dietary phosphates were analyzed, the diet higher in phosphates, according to Dr. Cho, “caused an increase in the size of the tumors and stimulated growth of the tumors.”
Dr. Cho said that while the 0.5 amount of phosphate was defined as close to the equivalent “normal” amount in the average human diet today, the real-world equivalent may be closer to the 1.0 amount or may even exceed it. “In the 1990s, phosphorous-containing food additives contributed an estimated 470 mg per day to the average daily adult diet,” Cho said. “However, phosphates are currently being added much more frequently to a large number of processed foods, including meats, cheeses, beverages, and bakery products. As a result, depending on individual food choices, phosphorous intake could be increased by as much as 1000 mg per day.”
Future studies will seek to determine “safe” levels of inorganic phosphates. Future research will also address possible involvement of phosphates in the development of lung cancer in smokers, since up to this time no one has known why some smokers develop lung cancer while others never do.
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