Scientists Figure Out How Alcohol Lowers Blood Sugar

Patrick Totty

Swedish scientists have found that alcohol lowers blood sugar by redirecting blood within the pancreas and sending massive amounts of it to the islets.

The finding by the Karolinska Institute in Stockholm, Sweden, is the first to show how alcohol is able to lower blood sugar levels. What happens is that by sending more of the pancreas's internal blood flow to the islets, alcohol spurs insulin production, which in turn lowers glucose levels.

The scientists injected rats with ethanol alcohol and noted that blood flow to the islets increased fourfold. The alcohol did not affect the amount of blood reaching the pancreas, only the distribution of blood within it.

The study also found that alcohol induced the changes in blood flow by affecting nitric oxide, a chemical compound that medical studies suggest is instrumental in glucose transport and the actions of insulin. Alcohol also affected the vagus nerve, which descends from the brain and into the abdomen and, among other things, signals organs there to secrete.

Source: Endocrinology, January 2008

Demand for health care help booming

Michigan's health care industry, the state's largest employer, desperately needs thousands of workers to fill jobs with critical shortages.

That may include you -- autoworkers, social workers, accountants, computer technicians and others laid off in one of the nation's worst recessions.

As jobs evaporate, the health care industry remains a field with job growth, benefits and, usually, stability.

"It's a very strong forecast for health care for a long time to come," said Andy Levin, deputy director of Michigan's Department of Labor and Economic Growth. ....more

Waist Size Predicts Stroke Risk

A large waist circumference, which is known to raise the risk of cardiovascular disease, may also raise the risk of stroke or mini-stroke, researchers from Germany report.

A large waistline seems to be a better indicator of a person's risk for suffering a stroke or mini-stroke, also known as "transient ischemic attack" or TIA, than a person's overall body weight, they report.

Dr. Tobias Back at Saxon Hospital Arnsdorf in Arnsdorf/Dresden and colleagues investigated the extent to which various markers of obesity were associated with the risk of stroke or mini-stroke in 379 adults with a history of stroke or TIA and 758 stroke-free controls of similar age and gender.

While being overweight in general (that is, having a high body mass index or BMI) increased the risk of stroke, this association became nonsignificant after the investigators accounted for "confounding" factors, like being physical inactive, smoking, having high blood pressure or diabetes.

However, being fat around the middle remained strongly associated with an increased risk of stroke or TIA.

For example, individuals with the highest so-called "waist-to-hip ratio" had a greater than 7-fold increased risk of stroke or TIA compared with those with the lowest waist-to-hip ratio.

Waist-to-hip ratio is calculated by dividing the circumference of the waist by the circumference of the hips. More belly fat results in higher ratios.

"If the waist-to-hip ratio values were greater than 0.97 for men and 0.84 for women, then individuals faced almost 8 times increased risk for stroke compared to individuals with a waist-to-hip ratio less than 0.92 in men or less than 0.78 in women," Back stated.

A large waistline also showed a strong association with stroke and TIA. If the waist circumference was greater than 40.2 inches for men or 34.6 inches for women, the risk of stroke increased more than 4-fold compared with individuals with a normal waist size, according to the researchers.

SOURCE: Stroke, December 2008.

Dogs More Effective Than Prozac

By: Sylvia Booth Hubbard

Want to cut down on doctor visits and be more active? Get a dog! University of British Columbia professor and author Stanley Coren says dogs work better at reducing stress than the antidepressant Prozac.

A recent study published in the journal “Psychosomatic Medicine” found that positive effects produced by dogs included several signs of reduced stress, including lowered blood pressure, slowed heart rate and more relaxed muscles. And those relaxing effects were attained much more rapidly than pills. Having a dog close by reduced stress in as little as five minutes, where prescription medications can take weeks before taking effect.

“The data is absolutely unambiguous,” Coren told Canada.com. “This actually works better than having a loved one next to you.”

Amazingly, research shows that dog owners visit their doctors less often and are more physically active than non-dog owners. And seniors who own dogs are four times less likely to be victims of depression.

“It’s quite an amazing statistic,” said Coren, author of several books on how humans interact with dogs including “How to Speak Dog: Mastering the Art of Dog-Human Communication.”

Don’t take health tips from celebs if you know what’s good for you

From Madonna’s quest to “neutralise radiation” to Tom Cruise’s dismissals of psychiatry, celebrities are seldom shy about expressing their views on health and science – even when they appear not to know what they are talking about.

A roll call of public figures such as Cruise and Delia Smith have offered bogus advice or “quackery” this year, according to scientists and doctors. The charity Sense About Science is concerned that celebrities mislead the public when they endorse theories, diets or health products while misrepresenting the science involved.

Some – such as Oprah Winfrey and Kate Moss – espouse “detox” regimes, while others, such as Sharon and Kelly Osbourne, believe (mistakenly) that the Pill can cause cancer.

Nor are politicians exempt from lending credence to health myths. The US President-elect is among several American public figures who continue to suggest that the MMR vaccination is a potential cause of autism, despite an overwhelming weight of scientific evidence to the contrary.

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God's got it right again! Circumcision Reduces HIV Risk in Heterosexual Men

A new U.S. study has found that being circumcised significantly reduced the risk of HIV infection in heterosexual African American men known to have been exposed to the virus. The findings complement those of recently reported clinical trials in Africa, where interventional use of adult male circumcision similarly reduced the risk of HIV infection in heterosexual men. The findings of the new study, along with similar results from other studies, suggest that circumcision may protect other heterosexual males in the U.S. The promising new findings are reported in the January 1 issue of The Journal of Infectious Diseases, now available online.

Lee Warner, PhD, MPH, and colleagues at the Centers for Disease Control and Prevention (CDC) and the Johns Hopkins University School of Medicine studied the records of more than 26,000 African American men who had had HIV testing during visits to two Baltimore, Maryland, STD clinics from 1993 to 2000. The subjects selected for the study said that they did not inject drugs and had sex only with women. Their visits to the clinics were classified as involving known HIV exposure if there had been a recent notification of such exposure by a sex partner or by a clinic’s disease intervention specialists; clinic visits for other reasons were classified as involving unknown HIV exposure. By these criteria, the investigators found 394 visits with known exposure and 40,177 visits with unknown exposure.

In visits by men with known HIV exposure, being circumcised was associated with a 51 percent reduction in HIV prevalence (10.2 percent of circumcised men vs. 22.0 percent of uncircumcised men). In contrast, HIV prevalence did not significantly differ in circumcised compared to uncircumcised men with unknown HIV exposure (2.5 percent vs 3.3 percent).

The investigators noted that three other U.S.-based studies had previously suggested that circumcision may be associated with reduced HIV risk, but the findings were limited by small sample size or extremely low HIV prevalence and did not achieve statistical significance. Indeed, HIV prevalence in the United States is very low (about 0.4 percent), and the proportion of circumcised adult males is high (about 80 percent), which could make it hard for conventional observational studies (i.e., studies that are not clinical trials) to discern whether circumcision actually has a protective effect. By focusing on patients who had documented exposure to an HIV-infected female partner, the current study was able to reveal that there was indeed a protective effect. This approach, the investigators said, “represents a significant methodological advancement over most previous observational studies.”

In a separate editorial on the topic, Ronald H. Gray, MBBS, MSc, of Johns Hopkins University, pointed out that circumcision may be especially important for minority U.S. populations, including Hispanic as well as African American men—subgroups most at risk for HIV infection. He also noted that the American Academy of Pediatrics has thus far not recommended routine neonatal circumcision, and that Medicaid does not cover the procedure. “It is to be hoped,” he said, “that the paper by Warner et al., in conjunction with the weight of evidence from international studies, will persuade the Academy to recognize the public health importance of this surgery for prevention of HIV in minority U.S. populations.”

Fast Facts:

Recently reported clinical trials in Africa have shown that interventional use of adult male circumcision reduced the risk of HIV infection in heterosexual men.

The current U.S. study was able to show that circumcision significantly protected heterosexual African American men. It did so by focusing on subjects who had documented exposure to an HIV-infected female partner.

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Delicate decision: To circumcise or not?

Circumcision 'does not curb sex'

Health Scan: Surgery still sometimes needed to get rid of kidney stonesSome people know that if a person is diagnosed with kidney stones, he can be tr

Some people know that if a person is diagnosed with kidney stones, he can be treated non-invasively with a soundwave device called a lithotripter, which smashes the stones into tiny fragments. Another technique is to insert an optic fiber into the urinary tract to destroy the stones. But Dr. Mordechai Duvdevani of the andro-urology unit at Hadassah University Medical Center in Jerusalem's Ein Kerem notes that these treatments are not so simple, and that the condition may still require minimally invasive surgery.

Writing in the latest issue of Urology Updates published by Medical Media, Duvdevani says these procedures are sometimes not successful - especially when stones are larger than 20 millimeters in diameter or very dense. In some cases, the fragments don't flush out of the body. Instead, a better technique, called percutaneous nephrolithotomy, is recommended.

The urologist explains that kidney stones result when there are bacteria able to break down uric acid and allow minerals to accumulate in the urinary tract. Antibiotics are not enough to get rid of these stones, as layer after layer of minerals accumulate. Sometimes, kidneys that are congenitally shaped differently than the norm are more prone to stones.

In percutaneous nephrolithotomy, which is performed under general anesthesia in one to four hours, a path is created to the kidney via the hip. Ultrasound, laser or other energy-based devices are introduced to smash the stones in situ and "vacuum" them out. Sometimes a supportive stent in inserted into the urethra that remains for a day or two. The procedure takes so long because the path must be at exactly the right location, angle and size. Sometimes a second path has to be created. The patient is hospitalized for two days to a week. Serious complications, writes Duvdevani, are rare.

Nephrolithotomy can be used by a well-trained team on a wide variety of patients, he concludes, including those with chronic illness and anatomical changes in the urinary tract. As kidney stones can recur, patients should be followed up.

Statin Warning for Women

Pregnant women or those hoping to start or extend a family should avoid using the cholesterol-lowering drugs statins, say scientists.

Current clinical guidelines already recommend that women who are pregnant should stop taking statins but the advice is based on the knowledge that cholesterol is essential for normal fetal development.

Indeed, a 2007 study examining the risk of congenital anomalies in children of pregnant women using statins suggested that the detrimental effects of the drugs may be restricted to fat-soluble or 'lipophilic' statins only.

But new research from The University of Manchester has shown that even water-soluble or 'hydrophilic' statins, such as pravastatin, can affect placental development leading to worse pregnancy outcomes.

"The rapid rise in obesity and type-2 diabetes is a major health issue and affected individuals are often treated with statins to lower circulating cholesterol levels and reduce the risk of heart disease," said Dr Melissa Westwood, a Senior Lecturer in Endocrinology based at the Maternal and Fetal Health Research Centre at St Mary's Hospital, Manchester.

"Given the evolving demographic profile of these conditions, such drugs are increasingly prescribed to women of reproductive age but the actions of statins are not limited to the regulation of cholesterol levels, as they can affect the production of other chemicals in the body too.

"Our study examined the effects that both lipophilic and hydrophilic statins had on a key biological system that is crucial for maintaining the normal function of the placenta, which acts as the nutrient-waste exchange barrier between mother and fetus."

The research, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), used a placental-tissue model that could be maintained in a viable state outside the body for several days and tested the effects of two different statins – one water-soluble and one that dissolves in fat.

As expected, the fat-soluble statin, cerivastatin, affected the placenta resulting in reduced growth but the researchers also found that pravastatin – the water-soluble statin thought to be potentially compatible for use in pregnancy – had the same detrimental effect.

"These results clearly show that the effect of statins on the placenta is not dependent on their lipophilicity as had previously been suggested," said Dr Westwood, whose findings are published in the Journal of Cellular and Molecular Medicine.

"While hydrophilic statins have not been reported to increase the incidence of fetal malformations, our research suggests that they will have a detrimental effect on placental growth, which is likely to result in poor pregnancy outcome.

"Healthcare professionals should continue to advise women to avoid the use of any type of statin once they plan to start a family or when a pregnancy is suspected or confirmed."

Four in Ten Adults Use Unconventional Medicine

About four in 10 U.S. adults and one in nine children are turning to unconventional medical approaches for chronic pain and other health problems, health officials said on Wednesday.

Back pain was the leading reason that Americans reported using complementary and alternative medicine techniques, followed by neck and joint pain as well as arthritis, according to the survey by the National Institutes of Health and the U.S. Centers for Disease Control and Prevention.

About 38 percent of adults used some form of complementary and alternative medicine in 2007, compared to 36 percent in 2002, the last time the government tracked at the matter.

For the first time, the survey looked at use of such medicine by children under age 18, finding that about 12 percent used it, officials said. The reasons included back pain, colds, anxiety, stress and attention deficit hyperactivity disorder, according to the survey.

The risks for children using these are unclear, they said.

Complementary medicine is used together with conventional treatment, while alternative medicine is used instead. This includes such things as herbal medicines and other natural products, chiropractic techniques, acupuncture, massage, meditation and others.

Many people feel these may work better for them than typical medical approaches, with fewer bad side effects. And so-called natural products have become big business, too, with various herbal medicines and others emerging as lucrative products.

"As I look at this data, what I'm most struck with is how much people are turning to CAM (complementary and alternative medicine) approaches as part of the management of chronic pain conditions, particularly chronic back pain, but also neck pain and musculoskeletal pain and headache," said Dr. Josephine Briggs, director of the U.S. National Center for Complementary and Alternative Medicine at the NIH.

"And from my days as an internist seeing patients in my office, I know that these are conditions that are hard to manage and tough to treat," Briggs told reporters.

Chiropractic care, acupuncture and massage therapy are among the complementary and alternative medicine techniques used for chronic pain, NIH researcher Richard Nahin said.

The survey results were based on responses from about 23,000 adults and 9,500 children nationwide.

Overall, the most common category of complementary and alternative medicine used was natural products such as herbal medicines and certain other types of dietary supplements other than vitamins and minerals.

Among these natural products used by adults, fish oil was the most commonly used. Nahin said it is used for such reasons as high cholesterol and high blood pressure.

Nahin said use of complementary and alternative medicine seems to be remaining at a significant but stable level, with most of the recent increases among those age 60 and up.

Deep breathing exercises, meditation and massage therapy all showed significant increases among adults. Overall, women and people with higher levels of education were more likely to use complementary and alternative medicine techniques.

Echinacea, a medicinal plant sometimes used to treat or prevent colds, was the most common of the natural products used by children, according to the survey. Echinacea use dropped among adults from 2002 to 2007, Nahin said.

Exercise Suppresses Appetite Hormones

A vigorous 60-minute workout on a treadmill affects the release of two key appetite hormones, ghrelin and peptide YY, while 90 minutes of weight lifting affects the level of only ghrelin, according to a new study. Taken together, the research shows that aerobic exercise is better at suppressing appetite than non-aerobic exercise and provides a possible explanation for how that happens.

This line of research may eventually lead to more effective ways to use exercise to help control weight, according to the senior author, David J. Stensel of Loughborough University in the United Kingdom.

The study, “The influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin and peptide YY in healthy males,” appears in the online edition of The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, published by The American Physiological Society. The authors are David R. Broom, James A. King and David J. Stensel of Loughborough University, and Rachel L. Batterham of University College, London.

There are several hormones that help regulate appetite, but the researchers looked at two of the major ones, ghrelin and peptide YY. Ghrelin is the only hormone known to stimulate appetite. Peptide YY suppresses appetite.

Ghrelin was discovered by researchers in Japan only about 10 years ago and was originally identified for its role as a growth hormone. Only later did its role in stimulating appetite become known. Peptide YY was discovered less than 25 years ago.

In this experiment, 11 male university students did three eight-hour sessions. During one session they ran for 60 minutes on a treadmill, and then rested for seven hours. During another session they did 90 minutes of weight lifting, and then rested for six hours and 30 minutes. During another session, the participants did not exercise at all.

During each of the sessions, the participants filled out surveys in which they rated how hungry they felt at various points. They also received two meals during each session. The researchers measured ghrelin and peptide YY levels at multiple points along the way.

They found that the treadmill (aerobic) session caused ghrelin levels to drop and peptide YY levels to increase, indicating the hormones were suppressing appetite. However, a weight-lifting (non-aerobic) session produced a mixed result. Ghrelin levels dropped, indicating appetite suppression, but peptide YY levels did not change significantly.

Based on the hunger ratings the participants filled out, both aerobic and resistance exercise suppressed hunger, but aerobic exercise produced a greater suppression of hunger. The changes the researchers observed were short term for both types of exercise, lasting about two hours, including the time spent exercising, Stensel reported.

“The finding that hunger is suppressed during and immediately after vigorous treadmill running is consistent with previous studies indicating that strenuous aerobic exercise transiently suppresses appetite,” Stensel said. “The findings suggest a similar, although slightly attenuated response, for weight lifting exercise.”